Project 561

Sodium Arsenite Studies in p53 +/- Mice

Research Investment

$242,259

Completion Year

2000

Completed

Principal Investigator

Raymond Tice

Project Manager

Jarmila Popovicova

Contractor

Integrated Laboratory Systems, Inc.

Abstract

Evaluates the carcinogenicity of sodium arsenite as a function of hepatic methyl donor status. Also investigates the ability of sodium arsenite to promote bladder carcinogenicity and skin carcinogenicity as a function of hepatic methyl donor availability. Reports findings from investigations using heterozygous p53 deficient male mice receiving chronic administrations of arsenic in drinking water. Research partner: USEPA and ACWA. Published in 2000.